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Qiacube Connect extraction systems ease the RT-PCR testing for the COVID-19 detection alongside several other applications, and automated purifications are useful in several downstream molecular biology applications.

Qiacube Connect

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QIAcube Connect performs the steps of lysis, binding, washing, and elution fully automatically with centrifuge column for processing DNA samples, RNA, and proteins, automatic processing of over 80 kits, and customer protocols.

QIAcube Connect, a new concept of nucleic acid extraction equipment, realizes automation by utilizing the advantages of QIAGEN spin-column technology, which has been loved for a long time as a global standard for DNA/RNA prep.

QIAcube Connect has built-in devices used in the manual experiment process and implemented the same automation as the manual by using the QIAGEN spin-column kit as it is. Everything is done in the equipment from sample lysis to elution, enabling "realization of personal automation equipment" with a small volume and economical price.

QIAcube Connect is redefining the benefits of automated sample processing. With advanced digital capabilities and connectivity, QIAcube Connect enables research labs to fully automate and track their popular QIAGEN spin-column purification and extraction protocols with the push of a button.

QIAcube Connect offers an augmented user interface that provides a new dimension of utility. Researchers can stay connected to their instrument via the integrated display and remotely with a tablet (included), which contains the pre-installed QIAcube Connect app, allowing for fast response times and monitoring runs while away. From QIAcube Connect.

Automatic Nucleic Acid Extractor (12 samples)

Molecular biology has a significant impact on the medical sciences. Processes like nucleic acid extractions and automated purifications are useful in several downstream applications of molecular biology. Closed architecture liquid handling platforms ease the extraction processes and aid in these applications. 

A noteworthy system with automated extraction and purification processes is the Qiacube Connect from Qiagen manufacturers. These extraction systems ease the RT-PCR testing for the COVID-19 detection alongside several other applications. The following information delineates the Qiacube system and its applications. 

Qiacube Connect Purification System: 

Qiacube, as mentioned above, is one remarkable extraction and purification system from the Qiagen company. These systems are intended to be operated by trained professionals for molecular biology applications and extractions of nucleic acids from different samples. 


The following are the device specifications of the Qiacube Connect system. 

  • Dimensions/ Size – 65 x 58 x 62 cm. 
  • Weight – 71.5 kg. 
  • Capacity – up to 12 samples per run 
  • Operating Temperature – 18-28 degrees centigrade 
technical data Power: 100–240 V AC, 50/60 Hz, 650 VA Mains supply voltage fluctuations are not to exceed 10% of nominal supply voltages. Note: The apparent power can exceed 650 VA for up to 2 seconds during the centrifuge acceleration and can reach an approximate value of 1000 VA.; Fuse: 2x T6.3A L 250V; Overvoltage category: II
operating temperature 18 to 28ºC (64.4 to 82.4ºF)
relative humidity 15–75% (non-condensing)
place of operation For indoor use only
pollution level 2
environmental class 3K2 (IEC 60721-3-3)
transportationconditions –25°C to 60°C (–13°F to 140°F) in manufacturer's package; Max. 75% relative humidity (non-condensing); Environmental class: 2K2 (IEC 60721-3-2)
storage conditions Temperature: 15ºC to 30ºC (59ºF to 86ºF) in manufacturer’s package; Relative humidity: Max. 75% (non-condensing); Environmental class: 1K2 (IEC 60721-3-1)
instrumentdimensions Dimensions (hood closed): width 65 cm (25.6 in.), height 58 cm (22.8 in.), depth 62 cm (24.4 in.); Dimensions (hood open): width 65 cm (25.6 in.), height 86 cm (34 in.), depth 62 cm (24.4 in.); Mass: QIAcube Connect: 71.5 kg (157.6 lb.), Accessories: 3 kg (6.6 lb.)
centrifuge 10,640 rpm maximum, 12,000 x g maximum, swing-out rotor maximum 45°, 12 rotor positions
shaker Speed 100–2000 rpm, amplitude 2 mm, heating range of ambient temperature to 70°C (158°F), ramp-up time of <5 minutes from ambient temperature to 55°C (±3°C). The difference in the temperature detected by the internal sensor and the temperature of the sample liquid is approximate –2°C.
pipetting system Syringe size 1 ml, pipetting range 5–900 µl
table capacity Up to 12 samples per run
touchscreen 10.4” TFT Touchscreen, active area 211.2 x 158.4 mm, resolution 800*600 SVGA
data output USB stick: USB2.0; Compatible OS: Windows 8, Windows 7, Windows Vista, Windows XP (SP3 or later); Mac OS x 10,1 or later; Operating temperature range: 0ºC to 35ºC; Operating humidity range: 10 to 90% (with no condensation); Storage temperature range: –20ºC to 60ºC (–4ºF to 140ºF); Storage humidity range: 10 to 90% (with no condensation); Formatting: FAT32
uvlamp Wavelength: 278nm; Optical power: 200-300mW
specialfeature Handheld scanner; Scan pattern: Area Image (838 x 640-pixel array); Motion tolerance: Up to 610 cm/s (240 in/s) for 13 mil UPC at optimal focus; Symbol contrast: 20% minimum reflectance difference; Decode capability: Reads standard 1D, PDF, 2D, Postal and OCR symbology
software QIAGEN protocols are pre-installed on the QIAcube Connect.
altitude Up to 2000 m (6500 ft)


Qiagen manufactures its products with world-class features that suit modern needs. The following are some intriguing features of the Connect system. 

1. Remote Connectivity: 

Qiagen provides remote connectivity with its unique feature called QIAsphere. The Connect systems come incorporated with this feature that allows remote connectivity. Through this feature, the operators can focus on other tasks while the system performs its run. The system also sends push notifications for important instrument events. The users can also manage the reports and check the maintenance status using this feature. 

2. Barcode Scanner: 

The Qiacube connect machines kit also has a barcode scanner as an accessory. This handheld scanner makes it easy to track the samples. Also, these readers provide the tracking of the sample kit information throughout the process. 

3. Protocols suiting different samples: 

The Connect systems have many protocols pre-installed for different applications like purification processes of RNA, plasmid and genomic DNA, viral proteins and nucleic acids, etc. These protocols also apply for DNA and RNA cleanup. Operators can also request the company for customized protocols apart from the preprogrammed ones. 

4. UV Light Contamination: 

Qiacube systems have an inbuilt UV light that helps decontaminate the entire worktable of the operator. This prevents the crossover and cross-contamination between different samples being processed by the system. Built-in UV light function can completely remove the contamination of the workbench and prevent contamination of the sample. In addition, gDNA was almost undetectable on UV exposures (without wipe and cleaning procedures). 

5. Spin column technology

It is easy to use, and you can expect the same results as the manual by using the spin-column technology, which is the representative technology of nucleic acid purification/extraction. By using QIAGEN's various manual kits, there is no change in results even after automation, and manual supplementation is possible in case of need.

6. Centrifuge purification method

QIAcube Connect has a built-in centrifuge, heat block, shaker, pipettor, and prepper necessary for manual experimentation so that the manual method can be reproduced automatically.

7. 150 kinds of protocols provided

The built-in protocol is programmed as it is in the manual kit's handbook process. Therefore, you can expect results consistent with the results of using the manual kit, and there is no need to worry or verify changes in results due to automation.

 Qiacube Connect Advantages: 

Qiacube Connect systems are used in different applications as they are built with different features listed above. Some advantages of these systems are as follows: 

  • The connect systems from Qiagen fit in with academic research laboratories, biomedical research labs, pharmaceutical, and biotechnology labs. 
  • These systems can be used for different applications like sequencing and its analysis, genotyping, microbiome research, gene expression analysis, etc. 
  • The systems are incorporated with the latest and advanced automation and sample processing techniques to provide the results quickly. 
  • These connect systems are efficient in managing complex samples and aid in advanced streamlined applications. 
  • The systems’ large touchscreen eases protocol selection. The software sends on-screen messages to guide the operators through the workable setups. 
  • The automated load check ensures that the labware, samples, etc., are loaded correctly and avoids mistakes. 

Includes device body and QIAsphere Connectivity Pack B (option), installation / basic instruction manual, the product warranty (3 years), and product inspection (3 times within the warranty period)

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Qiacube Connect
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