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Cobas e 411 analyzer is fully automated, uses patented electrochemiluminescence, and combines the reliability of Roche/Hitachi systems with the analytical excellence of electrochemiluminescence, creating an excellent immunoassay system.

Cobas e411

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cobas e 411 analyzer is fully automated and uses patented electrochemiluminescence (ECL) technology to perform immunoassay analyses. It has been developed for various applications for quantitative and qualitative in vitro assays (including anemia markers and bone, cardiac and tumor markers, critical care, fertility/hormones, pregnancy care, and infectious diseases). The analyzer is available as a rack system or disk system.

The Cobas e 411 combines the reliability of Roche/Hitachi systems with the analytical excellence of electrochemiluminescence, creating an excellent immunoassay system. By providing 18 simultaneous immunology parameters 24/24 hours, the Cobas e 411 offers high availability and response times of 9 to 27 minutes. Multifaceted, it both automates immunoassays in small and medium-sized laboratories and serves to perform specialties in larger laboratories.

The extensive test menu sets the Cobas e 411 apart. Roche's Clinical Chemistry and Immunology test menu, the most extensive on the market, allows you to run routine and special parameters on the same analytical platform. The laboratory can thus provide differentiated and routine tests simultaneously and in good time, with maximum analytical quality.

Performing immunoassays as easily as clinical chemistry

The Cobas e 411 system is a fully automatic Autoanalyzer applied to the immune analysis, whose measurement basis is Electrochemiluminescence (ECL). ECL technology uses streptavidin-coated magnetic microparticles as a solid phase, antigen/antibody interactions, and interference suppression methods.

The measurement cell where the electrochemiluminescent reaction takes place allows obtaining results in 9 minutes (STAT Test) or 18 minutes at a speed of approximately 90 determinations per hour.

It is a patient-oriented, continuous access instrument that provides the laboratory with improvements that translate into extreme simplicity and ease of use, with reliable results and a robust instrument.

Roche Cobas e411 Chemistry Analyzer Features:

  • High sensitivity, reliability, and reproducibility of results due to ECL technology
  • Up to 18 assays can be run at a throughput of up to 86 tests/h
  • 9 min STAT applications for emergency sample assays (incl. TnT Gen. 5, Creatine-Kinase MB, Myoglobin, Parathyroid Hormone (PTH), and human Chorionic Gonadotropin (hCG)1
  • Carryover-free pipetting of samples to avoid cross-contamination
  • Automated sample rerun capability
  • Continuous random access and flexible STAT priority settings
  • The use of disposable tips for all sample pipetting delivers carryover free pipetting to avoid cross-contamination
  • Economic usage with high stabilities and convenient kit sizes
  • High uptime of 98.6%
  • Low system maintenance time
  • Fully automatic immunological analyzer with up to 88 t / h.
  • It needs the shortest time to obtain the final result of all immunological analyzers – between 9 and 18 minutes. This is because the measurement method is ECL, which also allows a wider measurement range and greater sensitivity and needs smaller quantities of serum.
  • Possibility of continuous addition of samples at any moment of the process.
  • Possibility of setting urgent samples under STAT.
  • The unique concept of programming is just by inserting the reagents, calibrators, controls, and serums into the instrument and its launch. At the start, the instrument detects the barcode and starts working. This option increases efficiency in the laboratory.
  • A wide range of tests of over 75 covers the 7 different areas of indication. It is desirable to note that, unlike some instruments, there is no need for any selectivity through indication areas by defining the tests.
  • The reagents do not need any preparation (Ready To Use); they are on the drive with temperature control.
  • During the work at each pipetting, the reagents open and close automatically, so they are protected from external influences in every moment of the process.
  • This possibility to automatically open and close the reagents and temperature control increases the durability of the reagents inserted on the instrument to 60 days, even for the most sensitive tests.
  • Great stability of calibration of the lot has changed significantly reduced costs.
  • In the reliability of the results in every moment of the process, despite the increased stability of reagents and calibrations, also contributes to the detection level and opening coagulum (Clot Detection).
  • The possibility of transmission and contamination of the sample is reduced by using special pipettors for one use only at any pipetting of serum or reagent. This is another fact that increases the reliability of the results.
  • Ability to work with serum, plasma, and urine.
  • System software is perfected and standardized with all Cobas platforms. Performance of the PC – is significantly improved compared to the Elecsys 2010. Here are the biggest changes made in respect of Elecsys 2010 to simplify the system for the user.


  • Easy to Operate
  • Innovative technology
  • STAT facilities for urgent sample
  • Unique programming-by-loading concept

Assay menu

  • Thyroid Function
  • Fertility / Hormones
  • Anemia
  • Tumor Markers
  • Cardiac
  • Maternal Care
  • Critical Care
  • Infectious Disease
  • Bone Markers

Three ways to achieve unmatched performance

As the heart of the Cobas e 411 analyzers, ECL technology delivers the unique combination of nine-minute STAT applications, high analytical sensitivity, and wide measuring ranges for unparalleled performance in immunochemistry.

  • Wide measuring ranges reduce the amount of tests rerun due to out-of-range results


-Estradiol range of 5 – 4,300 pg/mL

-Progesterone range of 0 – 60 ng/mL

-total-PSA range of 0 – 100 ng/mL

  • High analytical sensitivity enables the use of innovative tests and requires less sample volume examples:

-Troponin T 4th gen. with <10% cv at 95th population percentile

-hCG+‚ and TSH requires 10 and 50 μL sample volume, respectively

  • Nine minutes STAT applications deliver unmatched turnaround time for emergency samples

-hCG+ß, Troponin T 4th Gen., CK-MB, Myoglobin, PTH*

Roche Cobas e411 Specifications

Fully automated, immunoassay analyzer for random access processing of ECL-based immunoassays (cobas e system format)
Types of modules
  1. cobas e 411 disk analyzer
  2. cobas e 411 rack analyzer
  1. Optional System Table (cabinet); Optional System Table Extension (for printer)
System components
Self contained bench top analyzer comprising an analytical unit and a customized user interface
System interfaces
RS232 serial interface, bidirectional
Up to 86 tests/hour
Number of reagent channels
18 channels (reagent slots) for maximum of 18 tests
Programmable test parameters
N/A, programming-by-loading (PBT) concept, application data are transferred without operator intervention from the 2D barcode of the reagent pack (RP) into the instrument database
Sample material
Serum/plasma, urine, others
Sample input/output
  1. Disk Model: 30 positions for samples, calibrators and controls
  2. Rack Model: 15 racks with 5 samples each (= 75 samples in/out)
  3. STAT port: STAT samples are processed with priority
Sample volume
10 – 50 μl
Sample clot detection
Standard (pressure sensor)
Sample barcode types
Code 128; Codabar (NW 7); Interleaved 2 of 5; Code 39
Control unit
Microsoft® Windows® XP-based panel PC
Calibrator/QC input
cobas e system-specific barcoded CalSet vials on disk or racks
Calibration methods
Lot calibration (L-cal); Reagent Pack (RP) calibration (R-Cal)
QC methods
  1. Individual QC and cumulative QC
  2. Up to 100 controls pre-programmable
  1. Preventive QC after calibration of the stand-by cobas e packs
Data storage capacity
  1. The memory contains data files necessary for the analyzer and software to work together:
    • – Reagent Data File: Up to 300 reagent packs
    • – Sample Data File: Up to 2000 test records (for samples and controls)
    • – Calibration Data File: Up to 160 calibrators
    • – QC Data File: Capacity up to 100 controls
    • – Operating Parameter Data File: Up to 305 reagent applications
    • – Up to 20 operator IDs
Electrical requirements
  1. 230/110 Volts AC; 1,000 kVA (disk), 1,250 kVA (rack)
  2. Frequency: 50 Hz or 60 Hz +/- 0.5%
Water/Waste requirements
  1. Water: Bacteria free, de-ionized water supply, resistance of < 10 μS/cm
  2. Liquid waste: Onboard waste container (4 liter), direct drain optional
Operating conditions
  1. Ambient temperature: 18 to 32°C
  2. Ambient humidity: 20 to 80% RH (without condensation)
  3. Heat Output: 2,879 kJ/hr (analyzer unit)
  4. Noise Output: 60 dBA (stand-by), 63 dBA (operation avg.)
Physical dimensions
  1. Width (disk/rack): 120 cm / 170 cm 47.2 in / 67 in
  2. Depth (disk/rack): 73 cm / 95 cm 28.7 in / 37.4 in
  3. Height: 80 cm / 31.4 in (closed top cover) 109 cm / 43 in (opened top cover)
  1. Disk: 180 kg / 397 lbs
  2. Rack: 250 kg / 551 lbs


  • ANTIMULLERIAN HORMONE (AMH) Reagent for Roche Elecsys 2010 / Cobas E411
  • TROPONIN THS Elecsys Reagent for Roche Elecsys 2010 / Cobas E411
  • PRECICONTROL AMH for Roche Elecsys 2010 / Cobas E411
  • PAPP-A Elecsys Reagent for Roche Elecsys 2010 / Cobas E411
  • CALCITONIN Reagent for Roche Elecsys 2010 / Cobas E411
  • N-MID OSTEOCALSIN Elecsys Reagent for Roche Elecsys 2010 / Cobas E411
  • VITAMIN D TOTAL II Reagent for Roche Elecsys 2010 / Cobas E411 – 100 Test
  • CALSET CALSITONIN for Roche Elecsys 2010 / Cobas E411
  • FREE HCG beta Elecsys Reagent for Roche Elecsys 2010 / Cobas E411
  • ANTI-HCV II Elecsys Reagent for Roche Elecsys 2010 / Cobas E411
  • ANTI-HAV GEN.2 Elecsys Reagent for Roche Elecsys 2010 / Cobas E411

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Cobas e411

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